Lotrisone is an anti-fungal medication which is a lotion or cream and its active components are a combination of two drugs: a steroid (betamethasone) and an antifungal drug (clotrimazole). Clotrimazole inhibits growth of several types of fungi by affecting the process of fungal membranes formation. Betamethasone is a synthetic corticosteroid that suppress inflammation as well as the body’s immune response.Lotrisone cream should be gently massaged into the skin and around the area affected by fungi twice a day (morning and evening). Do not use bandage or wrapping over the treated area to avoid excessive absorption of the medication. Treatment of of tinea corporis or tinea cruris should not continue longer than two weeks while one of tinea pedis should not last longer than four weeks.Avoid getting of the Lotrione cream into your eyes. Steroid drugs influence activity of the adrenal, hypothalamic, and pituitary glands, can lead to excessive blood sugar levels, as well as to a Cushing’s syndrome characterized by acne, depression, excessive hair growth, humped upper back, insomnia, moon-faced appearance, muscle weakness, obese trunk, paranoia, stretch marks, stunted growth (in children), wasted limbs, and susceptibility to bruising, fractures, and infection.This medication cannot be used in children younger 17 y.o., in individuals with hypersensitivity to the components of Lotrisone, or to similar steroid and antifungal medications. Cautiousness should be exercised in adults over age 65.The most common adverse reactions are local reddening, blistering, burning, dry skin, decreased pigmentation, stretch marks allergic reactions like hives, flue symptoms, bacterial infection, irritated skin, peeling, rash, stinging, swelling, tingling sensation, edema.Long-term use or withdrawal of topical corticosteroids may worsen symptoms of psoriasis. An interval of at least 1 week is needed between the discontinuance of topical steroids and the beginning of treatment with anthralin (Psoriatec).If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.Misuse or overuse of Lotrisone on wide skin areas can cause disorders such as Cushing’s syndrome. Inform your doctor about it. Life treating overdose of Lotrisone is unlikely.Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not use after expiration term.We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.